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. 1998 Apr 14;95(8):4732–4737. doi: 10.1073/pnas.95.8.4732

Figure 1.

Figure 1

Potentiation of EPSCs evoked by activation of multiple synapses is graded and dependent on NMDA receptor activation. (A) The amplitude of EPSCs evoked by stimulation of many synapses can be potentiated in a graded manner. Thus pairing 10 stimuli with postsynaptic depolarization evoked a small amount of potentiation and subsequent pairing of 100 stimuli evoked further potentiation. Averages of 50 consecutive current traces from the baseline period, following 10 pairings and following 100 pairings are superimposed (Right). The response to a −2 mV hyperpolarization is shown prior to the synaptic response. (B) EPSCs are not potentiated by pairing 10 stimuli and 100 stimuli in the presence of 100 μM D-APV. Averages of 50 stimuli from the baseline period, following 10 pairings and following 100 pairings are superimposed (Right). (C) Summary of experiments showing 35 ± 2% (n = 10) potentiation with 10 pairings and a further 43 ± 2% (n = 10) potentiation with 100 pairings (•). Potentiation is completely blocked in paired experiments carried out in the presence of 100 μM D-APV (n = 10, □). (D) The potentiation observed following pairing of 10 stimuli and the additional potentiation evoked by pairing 100 stimuli are plotted for each individual experiment (n = 18).