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. 1998 Apr 14;95(8):4738–4742. doi: 10.1073/pnas.95.8.4738

Figure 2.

Figure 2

Factor Xa causes hypotension in vivo and vasodilation in the isolated rat mesentery. (A) Rats were injected with increasing amounts of factor Xa or catalytically inactive DEGR-factor Xa before determination of changes in mean arterial pressure (MAP). Data are the mean ± SEM for factor Xa (n = 8–10) or DEGR-factor Xa (n = 3). (B) Data depict a representative bioassay trace of Ach- and factor Xa-induced vasodilation in the perfused rat mesentery. Increasing amounts of Ach (10–100 pmol) or factor Xa (6.6–66 pmol) were given as bolus injections into the perfused rat mesentery in the absence or in the presence of l-NAME (100 μM), and perfusion pressures (PP) were monitored. (C) The experimental conditions are the same as in B. Responses in the presence of l-NAME are represented by open bars. Data are the mean ± SEM of the effect of factor Xa and Ach on vasodilation in the perfused rat mesentery expressed as percent relaxation (n = 3–7).