Table 2.
Synergistic effect of high pH and a norA mutation
| Drugs | Sensitivity
|
||||
|---|---|---|---|---|---|
| RN4222 (WT)
|
KLE 820 (norA−)
|
norA− at pH 9 vs. WT at pH 7.2 | |||
| pH 7.2 | pH 9 | pH 7.2 | pH 9 | ||
| Pentamidine | 10 | 0.3125 | 0.3125 | 0.0097 | 1,030 |
| EtBr | 5 | 0.078 | 0.3125 | 0.01 | 500 |
| Berberine | 60 | 3.75 | 7.5 | 0.23 | 260 |
| Palmatine | 200 | 12.5 | 50 | 0.78 | 256 |
| TPP | 15.6 | 0.48 | 1.98 | 0.12 | 130 |
| Benzalkonium chloride | 0.67 | 0.08 | 0.16 | 0.0104 | 64 |
| Chlorhexidine | 0.5 | 0.06 | 0.125 | 0.0156 | 32 |
| Puromycin | 20 | 2.5 | 20 | 2.5 | 8 |
| Norfloxacin | 1.25 | 1.25 | 0.33 | 0.33 | 4 |
MIC in micrograms per milliliter. TPP, tetraphenylphosphonium bromide.