Figure 5.

(a) Stereo view of the electron density for FX-2212a in difference electron density maps (contoured at 1.6σ) calculated after modeling the first EGF domain and the simulated annealing refinement. The final structure is superimposed. (b) Binding interactions of FX-2212a (magenta ball and stick) with Des[1–44] factor Xa in the form 1 crystal. The Cα backbone is shown in blue, and residues involved in interaction are shown as a yellow ball-and-stick model. Conserved hydrogen bonds in the three crystallographically independent molecules are shown in green and a unique hydrogen bond in this interaction is shown in orange.