TABLE 1.
Experimentally verified function of protein coded by photolyase blue light photoreceptor family gene and amino acid residue at residue number 353
| Sequence ID | Species | Verified function | aa at 353 |
|---|---|---|---|
| Class I CPD photolyase subfamily: | |||
| PHR_ECOLI (60) | Escherichia coli | Catalyze the light-dependent monomerization of CPD | Met |
| PHR_SALTY (61) | Salmonella typhimurium | Catalyze the light-dependent monomerization of CPD | Met |
| PHR_THET2 (62) | Thermus thermophilus | Catalyze the light-dependent monomerization of CPD | Met |
| PHR_THET8 (63) | T. thermophilus | Bind CPD | Met |
| PHR_VIBCH (64) | Vibrio cholerae | Bind CPD, involved in repair | Met |
| PHR_STRGR (65) | Streptomyces griseus | Complement phr-deficient E. coli | Met |
| PHR_HALSA (66) | Halobacterium salinarium | Complement phr-deficient E. coli | Met |
| PHR_SYNP6 (67) | Anacystis nidulans | Complement phr-deficient E. coli | Met |
| PHR_SYNY3 (55) | Synechocystis sp. | Complement phr-deficient E. coli, involved in repair of UV radiation-induced DNA damage | Met |
| PHR_YEAST (68) | Saccharomyces cerevisiae | Catalyze the light-dependent monomerization of CPD | Met |
| PHR_NEUCR (69) | Neurospora crassa | Complement phr-deficient E. coli | Met |
| CRY subfamily: | |||
| CRY1_HUMAN (70) | Homo sapiens | Circadian clock component, negatively regulate Per1 transcription independent of light | His |
| CRY2_HUMAN (70) | H. sapiens | Circadian clock component, negatively regulate Per1 transcription independent of light | His |
| CRY1_MOUSE (71) | Mus musculus | Blue light-dependent regulator of the circadian feedback loop, no photolyase activity | His |
| CRY2_MOUSE (71) | M. musculus | Blue light-dependent regulator of the circadian feedback loop, no photolyase activity | His |
| CRY1_CHICK (72) | Gallus gallus | Blue light-dependent regulator of the circadian feedback loop, no photolyase activity | His |
| CRY2_CHICK (72) | G. gallus | Blue light-dependent regulator of the circadian feedback loop, no photolyase activity | His |
| CRY1_ARATH (73) | Arabidopsis thaliana | Mediate blue light-induced gene expression | Val |
| CRY2_VIBCH (64) | V. cholerae | No photolyase activity | Ala |
| PHR1_SINAL (57,58) | S. alba | No photolyase activity | Val |
| 6-4 photolyase subfamiliy: | |||
| DROCPD1 (74) | Drosophila melanogaster | Complement phr-deficient E. coli, 6-4 photolyase | His |
| AB042255(75) | Xenopus laevis | Complement phr-deficient E. coli, 6-4 photolyase | His |
| AB017331(76) | A. thaliana | Complement phr-deficient E. coli, 6-4 photolyase | His |
| CRY-DASH subfamiliy: | |||
| CRYD_SYNY3 (54) | Synechocystis sp. | Bind DNA, repress transcription of eight genes | Gln |
| CRYD_VIBC (56,64) | V. cholerae | Bind RNA, photolyase activity on single-stranded DNA | Gln |