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Binding energy landscapes (as a function of TM5 versus TM6 rotation) for two adrenergic ligands. (a) Inverse agonist ICI-118551. (b) Full agonist norepinephrine. The red regions represent unfavorable binding energies and the blue regions represent favorable binding energies. The various ligand-stabilized states are marked by dark circles. The white circles represent the possible inverse agonist stabilized states.
