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Conformational switches in human β2AR. (a) Ionic lock in apoprotein. (b) Breaking of ionic lock by norepinephrine. (c) W2866.48 rotamer in the apoprotein conformation. The water mediated hydrogen bond between W2866.48 and D792.50 is highlighted. (d) Toggling of the W2866.48 rotamer by norepinephrine. (e) No change in the W2866.48 rotamer for the salbutamol-bound conformation (not toggled).
