TABLE 1.
Parameter values determined by fit to the experimental data | ||
---|---|---|
Airway model | ||
parameters | Values in our model | 95% range |
k1a | 0.5962 s−1 | [0.34, 0.88] |
k1b | 1.35 μM | [1.1731, 1.5272] |
kon1 | 0.000125 | [0.0001, 0.0002] |
kon2 | 0.8988 μM | [0.7551, 1.0377] |
koff1 | 0.4629 | [0.3992, 0.5132] |
koff2 | 20.035 | [17.7670, 21.7317] |
τp | 156.9 s | [132.8425, 171.6565] |
242.14 s−1 | [164.6281, 337.2143] | |
g1 | 0.1211 s−1 | [0.1123, 0.1281] |
Arteriole model | ||
parameters | Values in our model | 95% range |
kon2 | 0.000174 μM | [0.0001, 0.0006] |
koff2 | 120.84 | [107.6515, 136.7734] |
τp | 564.67 s | [533.6403, 595.8495] |
76.23 s−1 | [73.6590, 78.8780] | |
g1 | 0.03 s−1 | [0.0291, 0.0311] |
k1b | 0.7 μM | From Geguchadze et al. (31) and Fajmut et al. (32) |
Parameter values taken from Mijailovich et al. (8) | |||
fp1 | 0.88 s−1 | gp1 | 0.22 s−1 |
Other parameter values | |||
β | 2 | γ | 44.87 |