TABLE 3.
Parameters and initial conditions of the receptor subsystem for simulation of growth-factor receptor (GFR) and T-cell receptor (TCR) behavior
| GFR | TCR | |
|---|---|---|
| Parameter | ||
| rtotal | 0.2 | 0.2 |
| c1 | 0.05 | 0/0.05 |
| c2 | 1 | 1 |
| c–2 | 0.1 | 0.1 |
| c3 | 1 | 1 |
| c–3 | 0.01 | 0.01 |
| c4 | 1 | 0 |
| c–4 | 0.01 | 0 |
| c5 | 1 | 1 |
| c–5 | 1 | 1 |
| c6 | 1 | 0 |
| c–6 | 1 | 0 |
| c7 | = k3 | = k3 |
| c–7 | = p1 | = p1 |
| c8 | = k3 | = k3 |
| c–8 | = p1 | = p1 |
| c9 | 1 | 1 |
| c–9 | 0.01 | 0.01 |
| kp | 0.1 | 0.1/0.6 |
| k–Cbp | 0.02 | 0.01 |
| k+Cbp | 0 | 0.005 |
| kSHP | NA | 2 |
| k2;min | 0.3 | 0.3 |
| k2;max | 0.6 | 0.6 |
| ρRsrc | 1 | 1 |
| Initial conditions | ||
| Variable* | ||
| SHP | 0 | 1 |
| Cbp/PAGpY317 | 0.009 | 0.045 |
| Cbp/PAG:Csk | 0.172 | 0.869 |
| PTPαpY798 | 0.198 | 0.198 |
Parameters are in arbitrary, dimensionless units (see Methods).
*
Zero for all variables other than those noted in Table 3.