Fig. 5.

Baseline values for AD threshold, AD duration, seizure stage, and duration of behavioral seizures before each of four sequential CED infusions (test sessions I–IV) of ω-CTX-G and ω-CTX-M at various doses and vehicle in the experiments presented in Figs. 2 and 3. The values for test session I represent the kindling measures for 22 animals before any infusion (true baseline). The treatments in later test session (II–IV) were presented in random order. The baseline values were calculated by averaging seizure measures in response to at least three electrical stimulations before an infusion. Each bar represents the mean ± S.E.M. There were no significant differences between the mean values of any of the seizure measures among the four test sessions (two-way repeated measures ANOVA), indicating that the baseline before CED infusion was stable during repeated CED infusion and testing.