Table 3.

Imaging and microscopic features of benign notochordal cell tumors

Evaluation method	Features
Radiograph (n = 9)	Vague sclerosis (n = 5)
	Marked sclerosis (n = 1)
	Invisible (n = 3)
Bone scintigram (n = 2)	No abnormal uptake (n = 2)
CT scan (n = 7)	Osteosclerosis in vertebral body (n = 7)
	No bone destruction or cortical disruption (n = 7)
MRI (n = 8)	T1-WI (n = 8): low signal intensity
	T2-WI (n = 8): intermediate–high signal intensity
	Gd-DTPA T1-WI (n = 3): no enhancement
	No invasive soft tissue mass (n = 8)
Histology (n = 8)	Solid sheets of adipocyte-like vacuolated cells combined with less vacuolated eosinophilic cells of various degrees
	Round or polygonal pyknotic nuclei occasionally with polymorphism
	No lobular configuration
	No extracellular myxoid matrix
	Some cystic spaces containing eosinophilic colloid-like material
	No mitotic figures
	Poor vascular network
	Entrapped islands of hematopoietic bone marrow
	Sclerotic bone trabeculae affected
	Positive immunostaining for vimentin, cytokeratin (AE1/AE3, CK18), EMA, and S-100 protein

CT, computed tomography; MR, magnetic resonance; WI, weighted image; Gd; gadolinium; CK, cytokeratin; EMa, epithelial membrane antigen.