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Dose-dependent response of various agonists on PAR4. Concentration of proteases is presented as nanomolar, whereas peptide concentrations are presented as micromolar. EC50 values are estimated at 5 nM for thrombin and trypsin and about 100 μM for PAR4-activating peptide. ○, Thrombin; ▪, trypsin; ♦, PAR4 activation peptide.
