Table 1.
Cellular composition of helminth-induced granulomas
| Cell type Present in the granuloma | Heligmosomoides polygyrus | Schistosoma mansoni | ||
|---|---|---|---|---|
| Day 4 after primary innoculation | Day 4 after secondary innoculation | Mild pathology | Severe pathology | |
| AAM | − | +++ | ++ | − |
| CAM | − | − | − | ++ |
| Neutrophil | ++ | ++ | − | ++ |
| Dendritic cell | + | ++ | ++ | ++ |
| Eosinophil | ++ | ++ | +++ | +++ |
| TH1 cell | − | − | − | ++ |
| TH2 cell | − | ++ | ++ | −/++ |
| TH17 cell | − | − | − | ++ |
| CD8+ T cell | − | − | ++ | + |
| B cell and/or plasma cell | − | − | ++ | + |
AAM, alternatively activated macrophage; CAM, classically activated macrophage; TH, T helper.