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Synthesis of hapten 1. Conditions: (a) (Boc)2O, triethylamine,97%; (b) RuCl3/NaIO4, 48%; (c) CH2N2, 100%; (d) Cs2CO3, 54%; (e) 1N NaOH, 91%; (f) Boc-Pro/DIEA/HOBT, EDC, 0°C → room temperature (RT), 89%; (g) TFA, 0°C, 98%; (h) DIEA/HOBT; (i) + 6, EDC, 0°C → RT, 97%; (j) TFA, 0°C, 100%; (k) Boc-Ala/DIEA/HOBT, EDC, 0°C → RT, 55%; (l) TFA, 0°C, 100%; (m) Succinic anhydride/DIEA, 51%; (n) (COCl)2, DMSO, −78°C → −20°C, 68%.
