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Synthesis of hapten analog (inhibitor) 13 and the structure of 12. Conditions: (a) BH3⋅THF; (b) aqueous HCl, 96% in two steps; (c) Boc-Pro/EDC/HOBT, 0°C → room temperature (RT), 94%; (d) TFA, 0°C, 96%; (e) DIEA/HOBT, 0°C; (f) + 6, EDC, 0°C, 91% in two steps; (g) TFA, 0°C, 92%; (h) N-acetyl-Ala/DIEA/HOBT, EDC, 0°C → RT, 53%; (i) Dess-Martin periodinane, −78°C, 82%.
