TABLE 2.
MONOSOMY 3 ANALYSIS OF UVEAL MELANOMA IN 140 CASES USING FINE-NEEDLE ASPIRATION BIOPSY (FNAB): FACTORS PREDICTIVE OF MONOSOMY 3*
| VARIABLE | MONOSOM Y 3 (n = 44) | DISOMY 3 (n = 76) | P VALUE† | P VALUE‡ | OR | 95% CI |
|---|---|---|---|---|---|---|
| Univariable Analysis | ||||||
| Age (yr), mean (SD) | 60.2 (12.8) | 58.6 (13.9) | 0.531§ | 0.288 | 1.01¶ | 0.98, 1.04 |
| Race, white vs Hispanic | 44 (100%) | 75 (98.7%) | 1.000 | 1.000 | ||
| Sex, male vs female | 28 (63.6%) | 40 (52.6%) | 0.258 | 0.242 | 1.58 | 0.74, 3.37 |
| Eye, left vs right | 22 (50.0%) | 32 (42.1%) | 0.179 | 0.403 | 1.38 | 0.65, 2.90 |
| Visual acuity, 20/20 vs <20/20 | 12 (27.3%) | 20 (26.3%) | 1.000 | 0.909 | 1.05 | 0.46, 2.43 |
| Symptoms | ||||||
| Floaters vs loss visual field | 1 (2.3%) | 4 (5.3%) | 1.000 | 1.000 | 1.00 | 0.07, 14.64 |
| Asymptomatic vs loss visual field | 15 (34.1%) | 28 (36.8%) | 0.471 | 0.372 | 2.14 | 0.40, 11.40 |
| Blurred vision vs loss visual field | 19 (43.2%) | 29 (39.2%) | 0.301 | 0.254 | 2.62 | 0.50, 13.70 |
| Photopsia vs loss visual field | 4 (9.1%) | 5 (6.6%) | 0.350 | 0.262 | 3.20 | 0.42, 24.42 |
| Metamorphopsia vs loss visual field | 2 (4.5%) | 2 (2.6%) | 0.521 | 0.277 | 4.00 | 0.33, 48.66 |
| Location | ||||||
| Ciliary body vs choroid | 2 (4.8%) | 2 (2.7%) | 0.601 | 0.488 | 2.03 | 0.27, 15.03 |
| Ciliochoroidal vs choroid | 6 (14.3%) | 4 (5.3%) | 0.162 | 0.101 | 3.04 | 0.81, 11.51 |
| Tumor quadrant | ||||||
| Macula vs superior | 7 (15.9%) | 6 (7.9%) | 0.177 | 0.112 | 2.86 | 0.78, 10.47 |
| Inferior vs superior | 13 (29.5%) | 15 (19.7%) | 0.197 | 0.147 | 2.13 | 0.77, 5.91 |
| Temporal vs superior | 10 (22.7%) | 22 (28.9%) | 1.000 | 0.834 | 1.12 | 0.40, 3.11 |
| Nasal vs superior | 3 (6.8%) | 5 (6.6%) | 0.684 | 0.634 | 1.47 | 0.30, 7.25 |
| Anteroposterior location | ||||||
| Macula vs macula to equator | 7 (15.9%) | 6 (7.9%) | 0.098 | 0.063 | 3.18 | 0.94, 10.72 |
| Equator to ora vs macula to equator | 9 (20.5%) | 14 (18.4%) | 0.299 | 0.271 | 1.75 | 0.65, 4.74 |
| Ciliary body + equator to ora vs macula to equator | 5 (11.4%) | 3 (3.9%) | 0.053 | 0.053 | 4.54 | 0.98, 20.95 |
| Ciliary body vs macula to equator | 2 (4.5%) | 2 (2.6%) | 0.314 | 0.334 | 2.72 | 0.36, 20.79 |
| Ciliary body + ora vs macula to equator | 1 (2.3%) | 1 (1.3%) | 0.478 | 0.487 | 2.72 | 0.16, 45.85 |
| Distance optic disc (mm), mean(SD), median | 5.97 (5.8), 4.8 | 4.18 (5.8), 2.0 | 0.019# | 0.122 | 1.05** | 0.99, 1.12 |
| Distance foveola (mm), mean(SD), median | 5.61 (6.3), 4.0 | 4.12 (5.4), 3.0 | 0.214# | 0.184 | 1.05** | 0.98, 1.12 |
| Largest base (mm), mean (SD) | 11.40 (3.4) | 9.93 (2.9) | 0.013§ | 0.016 | 1.17** | 1.03, 1.32 |
| Thickness (mm), mean (SD) | 4.92 (2.4) | 4.64 (2.3) | 0.517§ | 0.514 | 1.06** | 0.90, 1.24 |
| Thickness > 2 mm, positive vs negative | 40 (90.9%) | 67 (88.2%) | 0.088 | 1.000 | ||
| Fluid (negative vs positive) | 5 (11.4%) | 9 (11.8%) | 1.000 | 0.979 | 1.02 | 0.32, 3.27 |
| Symptoms (positive vs negative) | 26 (59.1%) | 47 (61.8%) | 1.000 | 0.948 | 1.03 | 0.46, 2.30 |
| Orange pigment (positive vs negative) | 23 (52.3%) | 40 (52.6%) | 0.844 | 0.782 | 1.13 | 0.51, 2.43 |
| Documented growth (positive vs negative) | 14 (31.8%) | 20 (26.3%) | 0.535 | 0.520 | 1.31 | 0.58, 2.95 |
CI, confidence interval.
*
Of the 140 samples, 120 had sufficient DNA for analysis and 20 samples were insufficient for analysis.
†
Fisher’s exact test.
‡
Logistic regression analysis/l.
§
Independent sample t test.
¶
Per 10-year increase.
#
Wilcoxon rank sum test.
**
Per 1-mm increase.