TABLE 3.

COMPUTER-BASED SYSTEM SENSITIVITY, SPECIFICITY, AND RECEIVER OPERATING CHARACTERISTIC AREA UNDER THE CURVE (AUC) FOR DETECTION OF PLUS DISEASE, COMPARED TO THE REFERENCE STANDARD OF MAJORITY VOTE AMONG 22 RECOGNIZED ROP EXPERTS

SYSTEM PARAMETER	SENSITIVITY*	SPECIFICITY*	AUC (SE)	AUC P VALUE†
Arteriolar IC	0.760	0.760	0.817 (0.085)	.002
Arteriolar diameter	0.590	0.590	0.560 (0.102)	.559
Arteriolar TI	0.700	0.700	0.707 (0.099)	.045
Venular IC	0.760	0.760	0.853 (0.072)	.001
Venular diameter	0.760	0.760	0.821 (0.082)	.002
Venular TI	0.640	0.640	0.744 (0.089)	.018
Linear combination I‡	0.766	0.766	0.835 (0.083)	.001
Linear combination II§	0.938	0.938	0.956 (0.036)	<.001
Linear combination III¶	0.938	0.938	0.967 (0.031)	<.001

IC, integrated curvature; SE, standard error; TI, tortuosity index.

^*For the computer-based system, values at the intersection points of the sensitivity and specificity curves in Figure 4 are displayed in this table.

^†Null hypothesis: true area under curve = 0.5 at level of significance P < .05.

^‡Comprising arteriolar IC and venular diameter.

^§Comprising arteriolar IC, venular IC, and venular diameter.

^¶Comprising arteriolar IC, arteriolar TI, venular IC, venular diameter, and venular TI.