TABLE 4.
RELATIONSHIPS BETWEEN INITIAL FLARE VALUES AND OTHER HOST AND DISEASE FACTORS AT BASELINE FOR CHILDREN WITH CHRONIC ANTERIOR UVEITIS
| BASELINE/FIRST FLARE† | ||
|---|---|---|
| FACTOR* | MEAN ± SD | MEDIAN (RANGE) |
| Age | ||
| <10 yr (n = 81) | 44.2 ± 61.2 | 15.1 (31–292.5) |
| ≥10 yr (n = 88) | 40.6 ± 59.9 | 22.9 (1.9–345.4) |
| P value‡ | .539 | |
| Gender | ||
| Female (n = 120) | 42.1 ± 56.3 | 22.1 (3.1–292.5) |
| Male (n = 49) | 43.0 ± 70.1 | 17.9 (1.9–345.4) |
| P value‡ | .292 | |
| Presence of systemic disease association§ | ||
| None (n = 103) | 45.0 ± 66.4 | 20.3 (1.9–345.4) |
| JIA (n = 64) | 38.0 ± 50.4 | 17.0 (3.1–274.3) |
| P value‡ | .714 | |
| Duration of disease¶ | ||
| <1 yr (n = 74) | 44.2 ± 64.8 | 21.7 (3.6–345.4) |
| ≥1 yr (n = 95) | 40.9 ± 57.0 | 20.0 (1.9–274.3) |
| P value‡ | .996 | |
| Immunomodulatory therapy | ||
| Yes (n = 66) | 47.0 ± 65.3 | 22.7 (3.5–292.5) |
| No (n = 103) | 39.4 ± 57.1 | 18.7 (1.9–345.4) |
| P value‡ | .255 | |
| Cells|| | ||
| < 1+ (n=51) | 25.0 ± 61.6 | 7.5 (1.9–345.4) |
| ≥1+ (n=116) | 49.1 ± 57.6 | 26.7 (4.1–274.3) |
| P value‡ | <.001 | |
| Keratic precipitates | ||
| Yes (n = 47) | 60.0 ± 67.3 | 32.5 (3.3–292.5) |
| No (n = 122) | 35.5 ± 56.3 | 15.2 (1.9–345.4) |
| P value‡ | <.001 | |
| Evidence of intermediate uveitis | ||
| Yes (n = 33) | 46.3 ± 51.9 | 28.1 (4.1–229.8) |
| No (n = 136) | 44.4 ± 62.4 | 16.4 (1.9–345.4) |
| P value‡ | .027 | |
| Papillitis | ||
| Yes (n = 31) | 45.2 ± 43.2 | 28.1 (3.3–160.2) |
| No (n = 130) | 42.2 ± 65.1 | 17.6 (1.9–345.4) |
| P value‡ | .079 | |
| Any vision-threatening complication** | ||
| Yes (n = 89) | 66.7 ± 74.2 | 39.0 (1.9–345.4) |
| No (n = 80) | 15.3 ± 14.6 | 8.7 (3.1–90.5) |
| P value‡ | <.001 | |
| Specific complications | ||
| Band keratopathy | ||
| Yes (n = 39) | 111.2 ± 85.4 | 76.1 (12.3–345.4) |
| No (n = 130) | 21.7 ± 27.1 | 13.6 (1.9–229.8) |
| P value‡ | <.001 | |
| Posterior synechiae | ||
| Yes (n = 50) | 84.4 ± 85.5 | 51.7 (4.5–345.4) |
| No (n = 119) | 24.8 ± 33.4 | 13.0 (1.9–229.8) |
| P value‡ | <.001 | |
| Cataract | ||
| Yes (n = 54) | 80.4 ± 88.4 | 48.8 (1.9–345.4) |
| No (n = 115) | 24.5 ± 27.2 | 14.4 (3.1–160.2) |
| P value‡ | <.001 | |
| Glaucoma/elevated intraocular pressure | ||
| Yes (n = 20) | 42.3 ± 44.1 | 30.6 (9.0–192.7) |
| No (n = 149) | 42.4 ± 62.4 | 19.1 (1.9–345.4) |
| P value‡ | .075 | |
JIA, juvenile idiopathic arthritis.
Factor at baseline unless otherwise specified.
Laser flare photometry value obtained at baseline or initial laser flare photometry value obtained after baseline (“first flare”), if none available at baseline.
Wilcoxon rank-sum test
Comparison excludes 2 patients with sarcoidosis (flare values of 38.8 pu/msec and 52.3 pu/msec).
Duration of disease prior to baseline, based on history, and interval from baseline to first flare, if applicable.
Anterior chamber cell determination from same examination as flare determination. Categorical scores converted to numerical values, as described in text.
Includes the following complications: band keratopathy; posterior synechiae; peripheral anterior synechiae; cataract; inflammatory membranes; glaucoma or elevated intraocular pressure; hypotony; macular edema; other.