Table 1.
Mouse and infant rat infection assays with wild-type and fnrKO strains.
| Mouse model | Rat model | ||||
|---|---|---|---|---|---|
| Bacterial strains | Challenge dose | Number of animals | Bacteraemiaa | Number of animals | Bacteraemiaa |
| MC58 wild type | 4.9 × 107 | 50 | 1.7 × 105* | nd | nd |
| MC-fnrKO | 5.1 × 107 | 50 | 9.8 × 103* | nd | nd |
| BZ232 wild type | 4.4 × 103 | nd | nd | 6 | 3.2 × 106** |
| BZ-fnrKO | 5.0 × 103 | nd | nd | 8 | 1.4 × 105** |
a
Values represent geometric means of the bacterial cfu ml−1 measured in each animal.
Four-day-old infant rats and 6-week-old BALB/c mice were infected with the indicated amount of bacteria. In the mouse infection model, animals were treated in five independent experiments, 10 mice per group. Bacteraemia was measured 18 h after intraperitoneal challenge.
*
P = 0.009.
**
P = 0.06.
The significance of differences in the levels of bacteraemia in repeated assays was estimated by two-tailed t-test.
nd, not determined.