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. 2008 Mar;172(3):761–773. doi: 10.2353/ajpath.2008.070473

Figure 9.

Figure 9

Increased expression of MMP-9 in Alport mesangial cells is regulated by ERK1/2 MAP kinase but not p38 MAP kinase. The same experimental strategy used in Figure 8 was used to characterize MMP-9 regulation in mesangial cells from Alport mice (top) and integrin α1-null Alport mice (bottom). RNA prepared from three independently derived sets of mesangial cells was analyzed in triplicate. Data were normalized to GAPDH, which was run in multiplex with each sample. Asterisks denote statistically significant differences in specific MMP expression when comparing results from vehicle-treated Alport or DKO mesangial cells with drug-treated Alport or DKO mesangial cells (P > 0.05). Wt, wild type; A, Alport; DK, α1-null Alport; H, herbimycin; PD, PD 98059; SB, SB 203580.