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. 2008 Mar;172(3):583–591. doi: 10.2353/ajpath.2008.070569

Figure 3.

Figure 3

RAGE transcripts and mRAGE/sRAGE protein are down-regulated in IPF lungs. a and b: Microarray analysis was performed on human IPF lung samples or control lung samples to compare expression of RAGE transcripts between IPF and control lungs. a: Summary of microarray data. Each point represents a single gene, plotted by its average expression in control lungs versus its average expression in IPF lungs. Points in color represent genes whose difference in expression in control versus IPF lungs reached significance. The point representing RAGE transcripts is indicated. b: Plot demonstrating the RAGE transcript level in each patient sample (represented by a single point). RAGE transcript levels are significantly decreased in IPF lungs compared to control lungs (P = 0.0000054). c: Western blot analysis on a different set of patient samples demonstrates a reduction in mRAGE (*P < 0.05) and sRAGE (**P < 0.01) protein levels in fibrotic areas of IPF lungs. Densitometry is shown with band intensities of mRAGE and sRAGE normalized to β-actin as a loading control.