Table 1.
Minimal fungicidal concentration (MFC) values of Candidaand Aspergillus strains to AMB (amphotericin B), FLC (fluconazole), ITC (itraconazole), VRC (voriconazole) and PSC (posaconazole), determined by CLSI protocols, in the absence and presence of propofol infusion
| Strains (n) | ||||||||
| MFC values* range μg.ml-1 | ||||||||
| Antifungals | Propofol(mg.ml-1) | C. albicans (5) | C. tropicalis (5) | C. parapsilosis (5) | C. glabrata (5) | A. fumigatus (5) | A. flavus (4) | A. niger (4) |
| AMB | 0 | 0.25 | 0.25–1 | 0.06–0.125 | 0.25–0.5 | 0.25–0.5 | 0.5–1 | 0.06–0.25 |
| 1.25 | 0.5–1 | 1 | 2 | 2 | 1–4 | 1–>16 | 0.25–1 | |
| 2.5 | 0.5–2 | 1–2 | 2 | 2 | 2–4 | 1–>16 | 0.25–1 | |
| 5 | 2–4 | 2 | 2–8 | 4–8 | 4–16 | 4–>16 | 0.5–2 | |
| FLC | 0 | 8–16 | 4–8 | 8–16 | 16 | nd | nd | nd |
| 1.25 | 16–>64 | >64 | >64 | >64 | nd | nd | nd | |
| 2.5 | 16–>64 | >64 | >64 | >64 | nd | nd | nd | |
| 5 | 16–>64 | >64 | >64 | >64 | nd | nd | nd | |
| ITC | 0 | nd | nd | nd | nd | 0.5–16 | 0.125–0.25 | 0.125–16 |
| 1.25 | nd | nd | nd | nd | >16 | 2–>16 | >16 | |
| 2.5 | nd | nd | nd | nd | >16 | 8–>16 | >16 | |
| 5 | nd | nd | nd | nd | >16 | 16–>16 | >16 | |
| VRC | 0 | 0.06–0.25 | 0.25–0.5 | 0.5–1 | 4–8 | 0.25–4 | 0.25–2 | 0.06–8 |
| 1.25 | 0.25–>2 | >2 | >2 | >8 | 2–8 | 0.25–2 | 1–16 | |
| 2.5 | 0.5–>2 | >2 | >2 | >8 | 2–8 | 0.5–4 | 1–16 | |
| 5 | 1–>2 | >2 | >2 | >8 | 2–8 | 0.5–4 | 1–16 | |
| PSC | 0 | 0.06–0.125 | 0.03–0.125 | 0.06–0.125 | 1–2 | 0.03–0.25 | 0.03–0.06 | 0.06–1 |
| 1.25 | 1–2 | >2 | 2 | 2 | 1–4 | 0.25–2 | 0.125–8 | |
| 2.5 | >2 | >2 | 2 | >2 | 1–4 | 0.5–2 | 0.25–16 | |
| 5 | >2 | >2 | >2 | >2 | 1–4 | 0.5–4 | 0.25–>16 | |
nd not done
* The mean value for each strain was considered