Table 1.
Confirmed CSE (n=155) | Probable CSE (n=233) | |
---|---|---|
Inclusion criteria for probable CSE | ||
Convulsions on arrival to hospital | .. | 180 (77%) |
Phenytoin or phenobarbital to stop seizures | .. | 48 (21%) |
Coma on admission, >1 seizure in previous 30 min | .. | 1 (<1%) |
Coma on admission, >10 seizures in previous 24 h | .. | 4 (2%) |
Demographic characteristics | ||
Age <12 months | 29 (19%) | 48 (21%) |
Male | 76 (49%) | 113 (48%) |
Clinical history | ||
History of any seizures | 36 (23%) | 83 (36%) |
Presented during first seizure of illness | 23 (15%) | 68 (29%) |
Focal onset seizure | 77 (50%) | 74 (32%)* |
Received >2 antiepileptic drugs during CSE | 63 (41%) | 5 (2%) |
Physical findings during CSE | ||
Malnutrition (WHZ <−2) | 50 (32%)† | 70 (30%)‡ |
Fever (axillary temperature ≥38·0°C) | 74 (48%) | 105 (45%)§ |
Hypoxia (oxygen saturation <92%) | 108 (70%) | 94 (40%)* |
Laboratory parameters | ||
Hypoglycaemia (blood glucose <2·5 mmol/L) | 18 (12%) | 23 (10)¶ |
Severe anaemia (haemoglobin <50 g/L) | 14 (9%) | 21 (9%)‖ |
Positive malaria slide | 101 (65%) | 152 (65%) |
Bacteraemia | 23 (15%) | 18 (8%)** |
Lumbar puncture done | 136 (88%) | 179 (77%) |
Acute bacterial meningitis | 20 (13%)†† | 13 (6%)‡‡ |
Primary diagnosis | ||
Malaria without febrile convulsion | 49 (32%) | 65 (28%) |
Febrile convulsion secondary to malaria | 35 (23%) | 57 (24%) |
Febrile convulsion secondary to other infection | 3 (2%) | 11 (5%) |
Acute bacterial meningitis | 15 (10%) | 16 (7%) |
Other infection without febrile convulsion | 10 (6%) | 13 (6%) |
Encephalopathy of unknown cause | 24 (15%) | 11 (5%) |
Anaemia | 11 (7%) | 21 (9%) |
Epilepsy | 2 (1%) | 21 (9%) |
Outcomes | ||
Died before discharge | 36 (23%) | 23 (10%) |
Neurological sequelae at discharge | 28 (18%) | 18 (8%) |
WHZ=weight-for-height Z score.
4 missing values.
7 missing values.
18 missing values.
1 missing value.
5 missing values.
2 missing values.
1 missing value.
19 missing values.
54 missing values.