TABLE 3.
ACTIVE MODULES
| Module Number | Number of Genes | Response | Functional Themes | Root Regulator | Selected Genes |
|---|---|---|---|---|---|
| 443 | 45 | Global induction following treatment | Receptors for interleukins and cytokines; eicosanoid metabolism | CHI3L3: Chitinase 3-like3-3 | PTGS1, PTGES, PTGER4 |
| 488 | 38 | Global induction following treatment | Adaptive immunity: Leukocytes; IL-17 signaling pathway; T-cell co-stimulatory pathways | EMR1: EGF-like hormone receptor with macrophage- restricted expression | CD3D, CD3G, CD2, PTPRC, LCK |
| 494 | 14 | Global induction following treatment | Chemokines and their receptors | CCL2: chemokine (C-C motif) ligand 2 | CHIA, CHI3L3, ARG1, MMP12 |
| 678 | 21 | Global induction following treatment | complement system | FCGR2B: Fc fragment of IgG, low affinity IIb, receptor (CD32) | C3, C3AR1, C1GA, C1GB, C1GC |
| 697 | 15 | Global induction following treatment and IL-13– dependent induction | Innate immunity response | CXCL5: chemokine (C-X-C motif) ligand 5 | CCR1, CCL2, CCL7 |
| 585 | 54 | Acute response to ovalbumin | JAK/STAT pathway | ID3: inhibitor of DNA binding 3 | JAK2, JUNB, IL4, IL10 IL1RA, IL4RA, IL17R, SOCS2 |
| 605 | 35 | Acute response to ovalbumin | Nitric oxide; Extracellular matrix molecules | RGS16: regulator of G protein signaling 16 | SERPINE, FAS, NFKBI |
| 649 | 6 | Acute response to ovalbumin | Chemokines with NF-κB binding site in their promoters. | CMKOR1: chemokine orphan receptor 1 | CXCL1, CXCL2, CXCL5 |
| 666 | 39 | Acute response to ovalbumin | Nitric oxide; NF-κB signaling; interleukins and their receptors | FZD2: frizzled homolog 2 (Drosophila) | IL1A, IL1B, IL1R2, CSF3, CCL3, CCL4, FOS, EGR1, MMP8 |
| 548 | 43 | Repression following treatment | Transcription factor activity and regulation of metabolism. | NUMB: numb gene homolog (Drosophila) | SOX17, SOX18, HOCB5, TOB, SMAD7 |
| 654 | 47 | Repression following treatment | Angiogenesis | IL1RL1: interleukin 1 receptor– like 1 | VEGFA, KDR, ANGPT1, FIGF, FIGF1 |
| 622 | 16 | IL-13–dependent induction | Genes repressed by IL-13 in human airway cells | MAFF: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) | PTGS2 |