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Role of p21 in TGF-β1–induced alveolar remodeling. After 2 weeks of dox induction, lungs were obtained from Tg (−) and Tg (+) mice with (+/+) and (−/−) p21 loci, fixed to pressure, and hematoxylin and eosin histologic stains (A; original magnification: ×10) and chord length (B) assessments were undertaken. A is representative of a minimum of five similar experiments. In B, the values represent the mean ± SEM of evaluations in a minimum of five mice (*P < 0.05, **P < 0.01).
