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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Insect Biochem Mol Biol. 2007 Dec 7;38(3):331–345. doi: 10.1016/j.ibmb.2007.11.012

Figure 6.

Figure 6

Illustration of the conservation of core apoptosis regulatory genes within Drosophila, An. gambiae and Ae. aegypti. The unrooted trees were built using neighbor end joining, complete deletion, p-distance with full amino acid sequences. The pathway illustrated is based on information obtained from studies using Drosophila. In Drosophila, thread inhibits Nc and Ice, while thread itself is inhibited by the IBM-containing proteins rpr, W, and grim. The initiator caspase Nc is responsible for cleaving and activating effector caspases including Ice and Dcp-1. Nc is activated by Ark, which for simplicity is not shown but which is also conserved in Ae. aegypti.