Table 3.

Medications With Gastric Prokinetic Properties

Medication	Mechanism(s) of Action	Dosing
Metoclopramide	-Dopamine D2 receptor antagonist	5–20 mg qid
	-5-HT4 receptor facilitation of acetylcholine release from enteric nerves
	-5-HT3 receptor antagonist
Erythromycin	Motilin receptor agonist	50–250 mg qid
Domperidone	Peripheral dopamine D2 receptor antagonist	10–30 mg qid
Bethanechol	Muscarinic receptor agonist	25 mg qid
Pyridostigmine	Acetylcholinesterase inhibitor	30–60 mg tid

tid = thrice daily; qid = 4 times daily