TABLE 3.
In vitro susceptibility for paired isolates tested at both the ring and the trophozoite stagesa
| Antimalarial |
P. falciparum
|
P. vivax
|
||||||
|---|---|---|---|---|---|---|---|---|
| No. of isolates | Median IC50 value (range) at the ring stage | Median IC50 value(range) at the trophozoite stage | P value | No. of isolates | Median IC50 value(range) at the ring stage | Median IC50 value(range) at the trophozoite stage | P value | |
| Chloroquine | 6 | 36.1 (11.9-55.0) | 99.7 (19.6-157.8) | 0.04 | 9 | 55.2 (18.3-171.8) | 2812 (384-4611) | 0.008 |
| Amodiaquine | 6 | 8.2 (2.6-16.2) | 15.2 (5.9-22.4) | 0.028 | 9 | 16.6 (6.7-37.9) | 24.2 (12.5-59.9) | 0.05 |
| Mefloquine | 6 | 4.6 (2.1-12.0) | 6.4 (2.4-34.1) | 0.075 | 9 | 7.9 (1.3-24.6) | 12.5 (1.9-25.0) | 0.123 |
a
In vitro susceptibility for paired isolates was tested at both the ring(>90%) stage and after culture in the absence of the drug to the trophozoite stage (>90%).