TABLE 1.

PKs of vancomycin and daptomycin achieved with each isolate tested^a

S. aureus strain	Antibiotic regimen	Cmax (mg/liter)	Cmin (mg/liter)	Half-life (h)	MIC (mg/liter)		AUC0-24/MIC (broth) ratio for D
					V	D
MSSA 616	V 1 g every 12 h	31.7 ± 0.4	10.3 ± 0.2	7.4 ± 0.9	1	0.125	536.4 ± 7.8
	D 6 mg/kg daily	106.8 ± 5.4	15.9 ± 0.4	8.4 ± 1.2			10,005.9 ± 248.9
	D 10 mg/kg daily	160.2 ± 4.5	25.5 ± 5.4	9.3 ± 1.6			14,480.8 ± 831.6
MRSA 675	V 1 g every 12 h	32.9 ± 0.4	10.4 ± 0.2	7.2 ± 0.3	2	0.25	277.1 ± 0.6
	D 6 mg/kg daily	107.2 ± 2.9	14.1 ± 0.9	8.0 ± 0.7			4,990.2 ± 86.7
MRSA 36132	V 1 g every 12 h	31.4 ± 0.2	9.4 ± 2.6	6.9 ± 1.0	2	0.25	257.4 ± 9.9
	D 6 mg/kg daily	109.3 ± 3.7	17.3 ± 5.3	8.8 ± 1.0			5,003.6 ± 118.8
MRSA WB1	V 1 g every 12 h	32.8 ± 0.3	9.5 ± 0.6	6.6 ± 0.6	2	0.25	271.8 ± 4.4
	D 6 mg/kg daily	98.3 ± 0.2	12.7 ± 0.6	7.9 ± 0.0			4,689.8 ± 19.2
MRSA WB2	V 1 g every 12 h	33.4 ± 1.5	6.8 ± 1.8	5.3 ± 0.6	2	0.25	243.3 ± 3.2
	D 6 mg/kg daily	106.1 ± 6.3	12.4 ± 3.9	7.6 ± 2.0			5,643.5 ± 180.0

^aV, vancomycin; D, daptomycin.