TABLE 2.
Concentrations of salinomycin in plasma, brain, liver, and SIC at t = 180 min after i.v. administration of 1 mg/kg
| Strain or parameter | Concn in plasma (ng/ml) | Concn in brain (ng/g) | Brain/plasma ratio | Concn in liver (μg/g) | Concn in SIC (μg/g) |
|---|---|---|---|---|---|
| WT | 72.5 ± 3.6a | 9.2 ± 0.7 | 0.13 ± 0.01 | 7.4 ± 1.0 | 0.21 ± 0.06 |
| Mdr1a/1b−/− | 269.7 ± 13.9b | 53.2 ± 10.1b | 0.20 ± 0.03b | 6.5 ± 1.1 | 0.29 ± 0.03 |
| KOc/WT ratio | 3.7 | 5.8 | 1.5 | 0.9 | 1.4 |
a
Values are means ± SD (n = 4).
b
P < 0.05, compared to WT mice.
c
KO, knockout.