TABLE 3.

AUCs of free drug (unbound to plasma protein) compared to measured and previously published MICs

Drug	Free AUC (μg · h/ml)	Actual MIC (μg/ml)	Published MIC90 (μg/ml)	Free AUC/actual MIC	Free AUC/ published MIC90
Levofloxacin	96.51	0.5	1.0	193.02	96.51
	295.86	0.5	1.0	591.72	295.86
	109.33	0.5	1.0	218.67	109.33
	89.83	0.5	1.0	179.66	89.83
	91.16	0.5	1.0	182.33	91.16
	109.35	0.5	1.0	218.69	109.35
	96.51	1.0	1.0	96.51	96.51
	266.24	0.5	1.0	532.48	266.24
	77.26	0.5	1.0	154.53	77.26
	82.48	0.5	1.0	164.96	82.48
Median		0.5	1.0	187.67	96.51
Mediana		0.5	1.0	180.99	93.84
Gatifloxacin	35.72	0.1	0.5	357.17	71.43
	30.46	0.2	0.5	152.31	60.92
	28.88	0.2	0.5	144.39	57.75
	44.01	0.2	0.5	220.07	88.03
	26.89	0.2	0.5	134.44	53.77
	36.05	0.2	0.5	180.25	72.10
	35.86	0.2	0.5	179.29	71.71
	36.98	0.2	0.5	184.92	73.97
	26.89	0.2	0.5	134.44	53.78
	24.62	0.1	0.5	246.23	49.25
Median		0.2	0.5	179.77	66.18
Moxifloxacin	25.67	0.5	0.5	51.33	51.33
	39.13	0.5	0.5	78.27	78.27
	27.17	0.5	0.5	54.33	54.33
	18.32	0.5	0.5	36.64	36.64
	21.08	0.5	0.5	42.16	42.16
	29.68	0.5	0.5	59.35	59.35
	31.51	0.5	0.5	63.02	63.02
	30.96	0.5	0.5	61.93	61.93
	30.78	0.5	0.5	61.57	61.57
Median		0.5	0.5	59.35	59.35

^aExcluding the two patients with the highest values.