TABLE 1.
Susceptibilities of S. pneumoniae (n = 151 isolates) to AR-709 and comparators
| Antibiotica | Susceptibility of isolatesb
|
MIC of antibiotic (mg/liter)
|
||||
|---|---|---|---|---|---|---|
| % S | % I | % R | Range | 50% | 90% | |
| AR-709 | ≤0.015-0.5 | 0.03 | 0.25 | |||
| Trimethoprim | 1->32 | 4 | >32 | |||
| Cotrimoxazole | 50.3 | 10.6 | 39.1 | 0.06-16 | 0.5 | 8 |
| Penicillin | 41.7 | 19.9 | 38.4 | ≤0.06-4 | 0.25 | 2 |
| Amoxicillin | 55.0 | 5.3 | 39.7 | ≤0.015-16 | 0.25 | 4 |
| Amox/clav | 55.0 | 6.0 | 39.1 | 0.03-16 | 0.25 | 4 |
| Azithromycin | 62.3 | 0.0 | 37.7 | ≤0.015->8 | 0.12 | >8 |
| Telithromycin | 98.0 | 1.3 | 0.7 | ≤0.015-4 | 0.5 | |
| Gatifloxacin | 98.7 | 0.7 | 0.7 | 0.12-4 | 0.25 | 0.25 |
a
Amox/clav, amoxicillin-clavulanic acid.
b
S, I, and R, susceptible, intermediate, and resistant, respectively. For ATCC 49619 (quality control), the MIC of AR-709 was ≤0.015 mg/liter.