TABLE 2.
Parameter estimates of PK-PD models with typical values
| Parametera | Typical value | SEb |
|---|---|---|
| Candida specific | ||
| Kg (h−1) | 8.64 × 10−1 | 3.21 × 10−2 |
| Kd (h−1) | 4.14 × 10−2 | 2.45 × 10−2 |
| Nmax (CFU·ml−1) | 1.48 × 106 | 5.54 × 105 |
| Fluconazole PK-PD | ||
| IC50 (μg·ml−1) | 9.29 × 10−2 | 5.67 × 10−2 |
| Imax | 6.75 × 10−1 | 3.42 × 10−2 |
| Caspofungin PK-PD | ||
| EC50 (μg·ml−1) | 2.51 × 10−4 | 4.62 × 10−5 |
| Emax (h−1) | 8.04 × 10−1 | 5.11 × 10−2 |
| Interindividual variability (% CV) | ||
| η (Nmax) | 225 | 218 |
| η (Emax) | 65 | 56 |
| Residual variability (% CV) | ||
| ɛ1 Fluconazole | 197 | 199 |
| ɛ1 Caspofungin | 96 | 63 |
a
CV, coefficient of variation; η, parameter for interindividual variability; ɛ1, parameter for residual variability.
b
SE, standard error.