Genetic relatedness of 123 ciprofloxacin-resistant S. pneumoniae isolates from Canada from 2003 to 2005. The figure shows the genetic relatedness of the isolates (from 60% to 100%) according to the Dice coefficient of similarity and information about the isolates and patients, including the age (in years) and sex (male [M] or female [F]) of the patient, ciprofloxacin MIC (CIP) (μg/ml), penicillin MIC (PEN) (μg/ml), and mutations in GyrA and ParC. The isolates in a group (three or four isolates with ≥80% genetic relatedness) and cluster (five or more isolates with ≥80% genetic relatedness) are indicated by shading. C-10, cluster 10 (a new cluster); G-11, group 11 (a new group).