TABLE 2.
Mutations generated by passage of virus in inhibitor-containing medium
| Inhibitor | Mutation(s)a detected on culture day:
|
|||
|---|---|---|---|---|
| 13 | 18 | 42 | 56 | |
| GSK364735 | No mutation | T124A | T124A | T124A |
| Q148R | Q146R | |||
| F121Y-T124A | Q148R | |||
| F121Y-T124A | ||||
| E10D-N17S-Q148R | ||||
| GS-9137 | V151I | T66I | T66A | T66I |
| T124A | T66I | E92Q | ||
| P145S | T124A | T124A | ||
| Q148K | P145S | P145S | ||
| T661-T124A | Q148K | Q148K | ||
| Q148R | Q148R | |||
| T661-T124A | T66I-T124A | |||
| T66K-T124A | T66K-T124A | |||
| Q148R-T124A | E92V-T124A | |||
| P145S-T124A | ||||
| Q146S-T124A | ||||
| Q148R-T124A | ||||
| T66I-V72A-A128T | ||||
| T66I-E92Q-T124A | ||||
| T66I-T124A-Q146L | ||||
| 3TC | M184I | M184I | Not determined | Not determined |
| M184V | ||||
a
Mutations listed in boldface (integrase mutations) and underlined mutations (RT mutations) corresponded to a >10-fold decrease in potency.