TABLE 1.

MICs of eight antibiotics for the P. mirabilis parental isolates and mutants exhibiting reduced susceptibility to triclosan

Parental strain and mutant	MIC (mg/liter) range fora:
	Triclosan	Trimethoprim	Ampicillin	Ciprofloxacin	Nitrofurantoin	Norfloxacin	Cephalexin	Nalidixic acid	Gentamicin
E. coli 10418	0.2	0.03-0.05	0.5-0.75	0.004	2-3	0.02	2-3	0.38-0.58	0.09
P. mirabilis B2	0.2	R	R	0.02-0.03	64-96	0.05	6	2-3	0.38
M 44	40	R	R	0.03	32-48	0.05	4-6	1.5-2	0.38
M 48	2	R	R	0.02	24-48	0.05	3-4	1.5-2	0.25-0.38
M 55	40	R	R	0.02-0.03	48	0.05	4	1.5	0.38-0.5
P. mirabilis NP14	0.2	R	16	0.06	32-48	0.25	3	3	0.13-0.25
M 19	40-60	R	12-16	0.05-0.06	32-48	0.19-0.25	4	2-3	0.13-0.19
M 21	5	R	16	0.05-0.06	48	0.19-0.25	3-4	3	0.13-0.19
M 23	5-10	R	12-16	0.05-0.06	32-48	0.19-0.25	3	2-4	0.09-0.13
P. mirabilis NP37	0.1	R	R	0.02	24	0.05-0.06	4-24	4-12	0.38-0.4
M 26	20	R	R	0.012	24-32	0.03	3	1.5-2	0.13-0.19
M 29	10	R	R	0.008-0.012	16-24	0.03-0.05	2-4	2-3	0.19-1
M 31	5	R	R	0.008-0.012	24	0.02-0.03	3-12	1.5-2	0.13-0.25
P. mirabilis NP43	0.2	0.4	0.4-0.5	0.01	48	0.05	4	2	0.1
M 12	40-60	0.19-0.25	0.13-0.19	0.006-0.008	12-32	0.02	1.5-2	1.5-2	0.06-0.09
M 17	40-60	0.25-0.4	0.19-0.25	0.006-0.012	12-32	0.02	1-2	2	0.06-0.09
P. mirabilis NP55	0.2	R	R	0.016	64-96	0.05-0.06	4-6	3	0.1-0.25
M 35	40	R	R	0.016-0.02	32-96	0.03-0.05	3	2-3	0.25
M 40	40-60	R	R	0.012-0.02	64	0.03-0.05	3-6	1.5-2	0.13-0.19
M 42	0.8-5	R	R	0.016	48-64	0.03	4	2-3	0.25

^aResults were obtained from triplicate determinations. R indicates that the Etest gave values of >256 μg/ml for ampicillin and >32 μg/ml for trimethoprim.