TABLE 2.
Effect of triclosan on times to catheter blockage, rates of catheter encrustation, pHs, and viable cells in bladder models inoculated with the wild-type P. mirabilis B2 strain and its mutantsa
| Strain | MIC of triclosan (mg/liter) | Time to catheter blockage (h)
|
Rate of catheter encrustation (μg Ca + Mg deposited/catheter/h)
|
pH of residual urine at time of catheter blockage or 48 h
|
Viable cells in urine at time of catheter blockage or 48 h (CFU/ml)
|
||||
|---|---|---|---|---|---|---|---|---|---|
| Water in balloon | Triclosan in balloon | Water in balloon | Triclosan in balloon | Water in balloon | Triclosan in balloon | Water in balloon | Triclosan in balloon | ||
| B2 (wild type) | 0.2 | 32 | >48 | 426.25 | 3.22 | 8.75 | 6.28 | 7.17 × 107 | 2.07 × 103 |
| M48 | 2.0 | 33 | >48 | 602.31 | 22.58 | 8.68 | 6.51 | 7.36 × 107 | 5.44 × 105 |
| M55 | 40.0 | 36 | 44 | 336.70 | 447.17 | 8.88 | 8.84 | 6.04 × 107 | 4.2 × 107 |
a
The values shown are means calculated from three replicate experiments.