TABLE 3.
Overall pharmacokinetic analysisa
| Time of analysis | Mean (SD) TPV Ctrough (ng/ml) |
|---|---|
| Wk 2 (n = 27) | 39,664 (17,477) |
| Wk 4 (n = 25) | 32,266 (19,323) |
| Wk 8 (n = 28) | 30,310 (24,374) |
| Wk 12 (n = 31) | 27,169 (19,423) |
| Wk 24 (n = 29) | 31,980 (18,800) |
| Wk 36 (n = 25) | 30,569 (21,226) |
| Wk 48 (n = 25) | 32,293 (18,078) |
| Overall mean (n = 36) | 31,406 (14,526) |
a
The mean TPV Ctrough was calculated as the mean of all available Ctrough measurements. Plasma samples obtained between 10 and 14 h postdosing were considered.