TABLE 1.

Results of renal histological examinations^a

Type of abnormality	Control group (n = 8)		20-mg/kg/8-h CMS group (n = 9)		30-mg/kg/12-h CMS group (n = 11)		150-mg/kg/12-h CMS group (n = 8)b
	No. of animals showing lesion	Severity of lesion	No. of animals showing lesion	Severity of lesion	No. of animals showing lesion	Severity of lesion	No. of animals showing lesion	Severity of lesion
Protein/cellular casts in proximal tubule	0	N/A	5	1+	3	1+, 2+, 3+	8	3+
Cortical proximal convoluted tubule necrosis	0	N/A	0	N/A	3	1+, 2+	7	3+
Pallor of outer stripe of proximal tubule	0	N/A	0	N/A	2	3+	0	N/A
Intracellular mineralization	0	N/A	0	N/A	0	N/A	7	3+
Nuclear pyknosis	0	N/A	0	N/A	2	1+	7	3+
Interstitial nephritis	0	N/A	0	N/A	2	1+	0	N/A
Total no. of animals showing lesions	0		5		7		8

^aA scale of 1+, 2+, and 3+ corresponding to mild, moderate, and severe changes, respectively, was used to grade lesion severity. N/A, not applicable.

^bRats received one dose only and were euthanized on day 1.