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(A) Vitamin B12 biosynthetic pathway and genes involved in the first five steps of biosynthesis. (B) Gene cluster for vitamin B12 biosynthesis in F. succinogenes. The genes highlighted by boxes (A) or cross-hatched arrows (B) are those with low homology to their respective counterparts in F. intestinalis. The hemA gene (filled arrow) was not detected under low-stringency Southern blotting conditions.
