FIG. 7.

Structure of the substrates' spatial positioning in the active-site pocket of WT TOM. The thioanisole molecule is manually docked within the active site and suggests a possible orientation of the substrate in the active site. The carbon atoms of thioanisole are colored in green. The aromatic ring is between the two residues L109 and V106 while the sulfur moiety of the molecule (yellow) points toward the diiron center. Substrate hydroxylation occurs at a bridging position between the two iron atoms (magenta).