TABLE 1.

Amino acid replacements in the circulating plasma virus of the four Mamu-B*08-positive macaques at 18 weeks after SIVmac239 infection

Type of substitution	No. of amino acid replacements
	Complete	Mixed base	Total
MHC class I associated
Mamu-B*08a	6	4	10
Mamu-A*01b	2e	4e	6
Mamu-A*02c	0	0	0
Not MHC associated
Suboptimal	6	1	7
Otherd	2	0	2
Unknown	1	7	8
Total	17	16	33

^aExpressed by r91003 (progressor), r01027 (controller), r00032 (EC), and r02019 (EC).

^bExpressed by r91003 (progressor) and r01027 (controller).

^cExpressed by r00032 (EC).

^dSubstitutions at position 67 in Env were previously detected in 33 of 35 SIV-infected macaques regardless of MHC class I genotype (60).

^eThis number includes concomitant changes in the overlapping open reading frame for Vpr (see Fig. S1C in the supplemental material).