TABLE 3.
P values for tests of neutral evolution, positive selection, and purifying selection in genes of vaccine strains and closely related field isolatesa
| Gene and strain |
P value for:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neutral evolution
|
Positive selection
|
Purifying selection
|
||||||||||
| S | Q1/76 | Q1/99 | V5/90 | S | Q1/76 | Q1/99 | V5/90 | S | Q1/76 | Q1/99 | V5/90 | |
| S1 | ||||||||||||
| Q1/76 | <0.01 | <0.01 | 1.00 | |||||||||
| Q1/99 | 0.94 | 0.82 | 0.47 | 0.41 | 1.00 | 1.00 | ||||||
| V5/90 | <0.01 | <0.01 | 0.81 | <0.01 | <0.01 | 0.41 | 1.00 | 1.00 | 1.00 | |||
| Vic S | 0.26 | 0.24 | 0.71 | 0.19 | 0.11 | 0.11 | 1.00 | 0.08 | 1.00 | 1.00 | 0.34 | 1.00 |
| S2 | ||||||||||||
| Q1/76 | 0.92 | 1.00 | 0.46 | |||||||||
| Q1/99 | 0.12 | 0.23 | 1.00 | 1.00 | 0.06 | 0.12 | ||||||
| V5/90 | 0.13 | 0.48 | 0.31 | 0.06 | 1.00 | 1.00 | 1.00 | 0.25 | 0.16 | |||
| Vic S | 0.06 | 0.70 | 0.36 | 0.27 | 0.03 | 1.00 | 1.00 | 0.14 | 1.00 | 0.35 | 0.19 | 1.00 |
| M | ||||||||||||
| Q1/76 | 0.32 | 1.00 | 0.17 | |||||||||
| Q1/99 | <0.01 | 0.32 | <0.01 | 1.00 | <0.01 | 0.17 | ||||||
| V5/90 | 0.32 | <0.01 | 0.32 | 1.00 | <0.01 | 1.00 | 0.17 | <0.01 | 0.17 | |||
| Vic S | 0.50 | 0.31 | 0.50 | 0.31 | 1.00 | 0.17 | 1.00 | 0.17 | 0.26 | 1.00 | 0.26 | 1.00 |
| N | ||||||||||||
| Q1/76 | 0.95 | 0.47 | 1.00 | |||||||||
| Q1/99 | 0.14 | 0.74 | 0.07 | 1.00 | 1.00 | 0.37 | ||||||
| V5/90 | 0.43 | 0.28 | 0.26 | 1.00 | 1.00 | 1.00 | 0.21 | 0.31 | 0.12 | |||
| Vic S | 0.86 | 0.62 | 0.70 | 0.25 | 0.43 | 1.00 | 1.00 | 1.00 | 1.00 | 0.31 | 0.34 | 0.11 |
a
Boldface type indicates that the alternative hypothesis has been accepted.