FIG. 1.

(A) Protein sequence alignment of C. elegans DOG-1 (CeDOG-1) and human FANCJ (HsFANCJ). Identical amino acids are shown in white on a black background; conserved amino acids are shown in black on a gray background. The sequences were aligned using ClustalW 1.83 and shaded with BoxShade 3.21. (B) Schematic of conserved domains of C. elegans DOG-1, chicken FANCJ (GgFANCJ), and human FANCJ as determined by the Conserved Domains Database. The BRCA1-interacting region of human FANCJ, including Ser990 and Phe993 (shown by the black square), are not conserved in chicken FANCJ or C. elegans DOG-1.