FIG. 3.

Treatment with anti-IFN-γ antibody reduces protective immunity in immunized β₂M^−/− mice. P. yoelii sporozoite-immunized β₂M^−/− mice were depleted of IFN-γ by i.v. injection of 1 mg of anti-IFN-γ MAb (MAb DB-1) on the day of sporozoite challenge and 24 h post-sporozoite challenge (45). Levels of rRNA in the livers were measured by RT-PCR at 40 h postchallenge. Results are shown as mean numbers of parasite 18S rRNA copies ± SD.