TABLE 1.
Immunization with irradiated sporozoites elicits sterile immunity in β2M−/− mice
| Mouse strain | Immunization inoculuma | No. protected/total no. of miceb | % Protected | Prepatent period (days) |
|---|---|---|---|---|
| β2M−/− | Irradiated P. yoelii sporozoites | 20/21 | 94 | 5.0 |
| None | 0/16 | 0 | 4.2 | |
| WT | Irradiated P. yoelii sporozoites | 9/9 | 100 | |
| None | 0/9 | 0 | 4.4 | |
| β2M−/− | Irradiated P. berghei sporozoites | 11/12 | 92 | 6.0 |
| None | 0/12 | 0 | 4.8 |
a
Pooled results from four independent P. yoelii experiments and two independent P. berghei experiments are shown.
b
Mice were challenged i.v. with 200 P. yoelii sporozoites or 2,500 P. berghei sporozoites, and patent parasitemia was determined by Giemsa staining of blood smears.