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. 2008 Jan 22;76(3):916–926. doi: 10.1128/IAI.01011-07

FIG. 3.

FIG. 3.

Disaggregation of CD19+ B-cell aggregates (brown staining) in the lungs of mice with chronic M. tuberculosis upon TNF neutralization by the MP6-XT22-neutralizing antibody at days 9 and 21 after initiation of treatment. Robust CD19+ B-cell nodules (arrowheads) are seen in the lungs of mice treated with control rat IgG. The lungs of mice treated with MP6-XT22 for 9 and 21 days demonstrate the disaggregation of CD19+ B-cell aggregates but still display remnants of B cells (arrowheads). Photomicrographs are representative and are at ×200 total magnification of 6-μm frozen sections immunoreacted to anti-CD19 antibodies.