TABLE 3.

Genes with differing expression in L. major- and L. donovani-infected macrophages

Gene namea	NCBI GeneID	Fold changeb
		L. donovani relative to latexc	L. major relative to latexc	Expression in L. donovani relative to L. majord
Tdag51/Phlda1	21664	12.6	(0.71)	17.8
Heat shock protein 1B (HSP70)	15511	8.2	(1.8)	4.5
Heat shock protein 1A (HSP72)	193740	15.3	(4.0)	3.8
PARP7	99929	6.2	(1.7)	3.7
Gadd45β	17873	8.0	(2.4)	3.4
Matrix metalloprotease 13	17386	2.4	(0.76)	3.1
RhoB	11852	2.6	(0.84)	3.1
Cox2	19225	10.3	(3.5)	3.0
Ferm domain containing 6	319710	4.4	(1.6)	2.8
Chymase 1	17228	(1.1)	(0.43)	2.6
Metallothionein 2	17750	15.5	(6.25)	2.5
Plasminogen activator inhibitor 2	18788	3.0	(1.3)	2.4
Connexin 43	14609	3.3	(1.4)	2.4
P34SEI-1	55942	2.2	(0.92)	2.3
Metallothionein 1	17748	6.3	(2.8)	2.3
Dual-specificity phosphatase 1	19252	2.9	(1.3)	2.3
SSAT	20229	1.8	(0.82)	2.2
RGC32	66214	5.4	(2.5)	2.2
Mitogen-inducible gene 6	74155	(1.7)	(0.77)	2.2
Protein phosphatase 2 Cα	19052	2.6	(1.2)	2.2
CCL4 (MIP1β)	20303	4.1	(1.9)	2.2
1190002N15Rik	68861	(1.3)	(0.63)	2.0
Kuppel-like factor 4 (Klf4)	16600	2.8	(1.4)	2.0
Tubulin α3B	22147	2.8	(1.4)	2.0
Estrogen-responsive finger protein	217069	(1.7)	(0.82)	2.0
Linker for activated T cells (LAT2)	56743	(0.56)	(1.2)	0.47

^aSome genes did not show statistically significant differences when macrophages infected with either species were compared with macrophages exposed to latex beads; however, there were significant differences between L. major- and L. donovani-infected macrophages, so they are included in this list.

^bParentheses indicate changes that were not statistically significant. Probe sets with statistically significantly different signal intensities between L. major and L. donovani macrophages were identified as described in Materials and Methods.

^cChanges relative to macrophages exposed to latex beads are included for context only.

^dDifferences between mean signal intensities.