TABLE 2.
Biological process(es) | Host protein(s) | Level of confidence in IDa at:
|
|
---|---|---|---|
30 min | 6 h | ||
Coagulation | Alpha-2-antiplasmin | High | Very high |
Antithrombin III | Very high | ||
Coagulation factor XIII | Very high | ||
Fibrinogen | Very high | Very high | |
Heparin cofactor 2 | Very high | ||
Hyaluronan binding protein 2 | High | ||
Kininogen 1 | Very high | Very high | |
Plasminogen | Very high | ||
Prothrombin | Very high | ||
Extracellular matrix | Fibronectin | Very high | |
Nephronectin | High | ||
Neutrophil collagenase/matrix metalloproteinase 8 | Very high | ||
Neutrophil gelatinase-associated lipocalin | Very high | ||
Vitronectin | High | Very high | |
Inflammation | Alpha-1-microglobulin/bikunin | High | Very high |
Calgranulin A/protein S100-A8 | High | ||
Cathelicidin antimicrobial peptide | Very high | ||
Chitinase 3-like protein 1 | Very high | High | |
Chitinase 3-like protein 3 | Very high | Very high | |
Complement C3 | Very high | Very high | |
Complement C4b | Very high | ||
Complement C5 | Very high | Very high | |
Complement C7 | High | ||
Complement C8 | Very high | High | |
Complement C9 | Very high | High | |
Complement factor B | Very high | ||
Complement factor H | High | ||
Granulin/epithelin | High | ||
Igs (11 identifications)b | Very high | Very high | |
Long palate, lung, and nasal epithelium carcinoma-associated protein 1 | Very high | ||
Long palate, lung, and nasal epithelium carcinoma-associated protein 3 | High | ||
Lysozyme | Very high | Very high | |
Myeloid bactenecin | Very high | ||
Palate, lung, and nasal epithelium clone | High | Very high | |
Serum amyloid A-1 | Very high | ||
Serum amyloid A-2 | High | ||
Serum amyloid A-4 | Very high | ||
Serum amyloid P component | Very high | ||
Metabolism | Serum paraoxonase/arylesterase 1 | Very high | |
Proteolysis | Alpha-1-antitrypsins 1-2 | Very high | Very high |
Alpha-1-antitrypsins 1-4 | Very high | Very high | |
Alpha-1-antitrypsins 1-5 | Very high | Very high | |
Alpha-1-antitrypsins 1-6 | Very high | Very high | |
Alpha-2-macroglobulin | Very high | ||
Histidine-rich glycoprotein | Very high | ||
Inter-alpha trypsin inhibitor heavy chain 4 | Very high | ||
Inter-alpha trypsin inhibitor heavy chain H2 | High | ||
Murinoglobulin-1 | Very high | ||
Myeloblastin | High | ||
Napsin-A | Very high | Very high | |
Plasma protease C1 inhibitor | High | ||
Serine proteinase inhibitor B1a | High | High | |
Serine proteinase inhibitor B6 | Very high | ||
Serine proteinase inhibitor B6b | Very high | ||
Serine proteinase inhibitor B9 | Very high | ||
Serine protease inhibitor A3C | High | ||
Serine protease inhibitor A3K | Very high | Very high | |
Serine protease inhibitor A3M | High | Very high | |
Serine protease inhibitor A3N | Very high | Very high | |
Whey acidic protein 4-disulfide core domain protein 2 | Very high | Very high | |
Regulation | α2-HS-glycoprotein/fetuin | Very high | Very high |
Protein-glutamine gamma-glutamyltransferase 2 | High | ||
Pulmonary surfactant-associated protein B | Very high | Very high | |
Pulmonary surfactant-associated protein D | Very high | Very high | |
Regulation and transport | Apolipoprotein A-I | Very high | Very high |
Apolipoprotein A-II | High | ||
Apolipoprotein A-IV | Very high | Very high | |
Apolipoprotein C-I | High | ||
Apolipoprotein C-III | High | Very high | |
Apolipoprotein E | Very high | ||
Apolipoprotein H/beta-2-glycoprotein I | High | ||
Signaling | Uteroglobin | Very high | Very high |
Stress response and regulation | Clusterin | Very high | Very high |
Transport | Apolipoprotein B | Very high | |
Ceruloplasmin | Very high | ||
Haptoglobin | Very high | Very high | |
Hemopexin | Very high | Very high | |
Mucin 5B | Very high | ||
Phospholipid transfer protein | Very high | High | |
Pulmonary surfactant-associated protein A | Very high | Very high | |
Serotransferrin | Very high | Very high | |
Serum albumin | Very high | Very high | |
Transthyretin | High | ||
Vitamin D binding protein | Very high | ||
Transport and metabolism | Apolipoprotein M | High | |
Unknown | Leubrin | High |
A high level of confidence in the identification (ID) indicates that the protein was confidently identified using one peptide, and a very high level of confidence in the identification indicates that the protein was confidently identified using two or more peptides.
A total of 11 different Ig proteins were identified in the analysis (see Table S1 in the supplemental material). The 11 different Igs were combined in this table for simplicity.