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Effect on replication in MDCK cells of recombinant WSN viruses with the introduction of synonymous changes within the highly conserved region of the PA vRNA
| Virus | Plaque titer |
|---|---|
| WSN wt | 6.1 × 107 |
| WSN PA51 | 3.3 × 105 |
| WSN PA52 | 1.6 × 106 |
| WSN PA53 | 4.3 × 104 |
| WSN PA54 | 9.0 × 104 |
MDCK cells were infected at 0.001 MOI and incubated for 48 h. Virus produced was titrated by plaque assay in MDCK cells. Results represent the average titer from two independent infections titrated in duplicate (n = 4).
